A drug that induces P-gp will lead to which change in the absorption of other drugs?

A drug that induces P-gp will lead to which change in the absorption of other drugs?

• A. Less absorption
• B. More absorption
• C. Greater duration
• D. Shorter duration

Answer: (A)

Inducing P-glycoprotein in the intestinal lining boosts the activity of this efflux transporter. For drugs that are P-gp substrates, more of the drug is pumped back into the gut lumen as it tries to cross the intestinal wall. This reduces the amount that actually enters the bloodstream, meaning less absorption and lower oral bioavailability. The other options don’t fit because increased absorption would come from inhibiting P-gp (not inducing it), and duration changes are related more to elimination than the initial absorption process.

Inducing P-glycoprotein in the intestinal lining boosts the activity of this efflux transporter. For drugs that are P-gp substrates, more of the drug is pumped back into the gut lumen as it tries to cross the intestinal wall. This reduces the amount that actually enters the bloodstream, meaning less absorption and lower oral bioavailability. The other options don’t fit because increased absorption would come from inhibiting P-gp (not inducing it), and duration changes are related more to elimination than the initial absorption process.