Intravenous administration is particularly useful for drugs with a narrow therapeutic index because it provides precise control of exposure.

Intravenous administration is particularly useful for drugs with a narrow therapeutic index because it provides precise control of exposure.

• A. True
• B. False
• C. Not applicable
• D. Sometimes

Answer: (A)

Precise control of drug exposure is essential for agents with a narrow therapeutic index because small changes in plasma concentration can flip between therapeutic and toxic effects. Intravenous administration directly delivers the drug into the bloodstream, giving 100% bioavailability and removing absorption variability. This allows rapid attainment of a target concentration and, if needed, tight adjustment of the dose rate through bolus dosing or controlled-rate infusion. By avoiding first-pass metabolism and unpredictable oral absorption, IV dosing provides a predictable concentration–time profile, which is critical when even slight over- or under-dosing can cause harm. A loading dose can quickly reach therapeutic levels, followed by a maintenance infusion to keep concentrations within a safe range. So the statement is true.

Precise control of drug exposure is essential for agents with a narrow therapeutic index because small changes in plasma concentration can flip between therapeutic and toxic effects. Intravenous administration directly delivers the drug into the bloodstream, giving 100% bioavailability and removing absorption variability. This allows rapid attainment of a target concentration and, if needed, tight adjustment of the dose rate through bolus dosing or controlled-rate infusion. By avoiding first-pass metabolism and unpredictable oral absorption, IV dosing provides a predictable concentration–time profile, which is critical when even slight over- or under-dosing can cause harm. A loading dose can quickly reach therapeutic levels, followed by a maintenance infusion to keep concentrations within a safe range.

So the statement is true.