What is the primary action of hyaluronidase that enhances absorption?

What is the primary action of hyaluronidase that enhances absorption?

• A. Breaking down connective tissue to increase absorption
• B. Vasodilation at injection site without tissue remodeling
• C. Inhibiting diffusion by thickening interstitial space
• D. Neutralizing enzymes in tissue

Answer: (A)

Hyaluronidase acts as a spreading factor by breaking down hyaluronic acid in the extracellular matrix of connective tissue. By hydrolyzing this component, the interstitial space becomes less viscous and less resistant to diffusion, allowing injected fluids or co-administered drugs to spread more easily and be absorbed more rapidly. This degradation of the connective tissue network is the primary mechanism that enhances absorption. Vasodilation at the injection site is not the main action of hyaluronidase, though improved spread can accompany diffusion. Thickening the interstitial space would hinder diffusion, not promote it. Neutralizing enzymes in the tissue is not what hyaluronidase does.

Hyaluronidase acts as a spreading factor by breaking down hyaluronic acid in the extracellular matrix of connective tissue. By hydrolyzing this component, the interstitial space becomes less viscous and less resistant to diffusion, allowing injected fluids or co-administered drugs to spread more easily and be absorbed more rapidly. This degradation of the connective tissue network is the primary mechanism that enhances absorption.

Vasodilation at the injection site is not the main action of hyaluronidase, though improved spread can accompany diffusion. Thickening the interstitial space would hinder diffusion, not promote it. Neutralizing enzymes in the tissue is not what hyaluronidase does.